Monday June 3 3 - All Day Bio International Convention
Monday June 3 – Thursday June 6 Bio International Convention San Diego Convention Center, 111 Harbor Dr, San Diego, CA 92101, USA Register BUILDING CONNECTIONS, BREAKING BARRIERS When the stakes are this high, we can’t go it alone. BIO unites a global network of business leaders, policymakers, investors and scientists for a common purpose: curing patients, protecting the planet, and nourishing humanity.
| Tuesday June 4 4 - All Day Bio International Convention
Monday June 3 – Thursday June 6 Bio International Convention San Diego Convention Center, 111 Harbor Dr, San Diego, CA 92101, USA Register BUILDING CONNECTIONS, BREAKING BARRIERS When the stakes are this high, we can’t go it alone. BIO unites a global network of business leaders, policymakers, investors and scientists for a common purpose: curing patients, protecting the planet, and nourishing humanity.
| Wednesday June 5 5 - All Day Bio International Convention
Monday June 3 – Thursday June 6 Bio International Convention San Diego Convention Center, 111 Harbor Dr, San Diego, CA 92101, USA Register BUILDING CONNECTIONS, BREAKING BARRIERS When the stakes are this high, we can’t go it alone. BIO unites a global network of business leaders, policymakers, investors and scientists for a common purpose: curing patients, protecting the planet, and nourishing humanity. - 12:00 pm – 1:00 pm Broad T-cell Receptor Repertoires in TIL and Differential Th1/2/17 Functional Phenotypes Associated with the Tumor Microenvironment
12:00 pm – 1:00 pm Broad T-cell Receptor Repertoires in TIL and Differential Th1/2/17 Functional Phenotypes Associated with the Tumor Microenvironment Tumor Infiltrating Lymphocyte (TIL) therapy is a personalized adoptive cell therapy (ACT) that has successfully treated patients with various solid tumor cancers. This therapy uses TILs— derived from a patient’s tumor, expanded, and re-infused back into the patient. It is known that the TME suppresses cellular anti-tumor responses, but TIL may contain a particular epigenetic imprint that enables them to remain active within the tumor. A better understanding of this imprinting, their functional phenotypes, and their unique T cell receptors (TCR) may enable us to design more effective T cell products for use as ACTs. Join us for a webinar featuring research conducted by Eric de Sousa, bioinformatician in the Markus Maeurer Lab at the Champalimaud Foundation, that showed differences in TCR repertoires and patterns of cytokine production within specific zones of the TME. Title: Broad T-cell Receptor Repertoires in TIL and Differential Th1/2/17 Functional Phenotypes Associated with the Tumor Microenvironment Date/Time: June 5, 2024, at 12:00 PM ET Highlights: - Spatial differences in TIL origin site (e.g., core vs. invasion front) reveal differences in
TCR repertoire and cytokine production. - TIL origin site determines antigen-specific Th1/Th2/17 cytokine production pattern.
- Observed patterns in TIL cytokine and TCR repertoire impact anti-cancer immune
response and may inform engineered cell therapies.
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| Thursday June 6 6 - All Day Bio International Convention
Monday June 3 – Thursday June 6 Bio International Convention San Diego Convention Center, 111 Harbor Dr, San Diego, CA 92101, USA Register BUILDING CONNECTIONS, BREAKING BARRIERS When the stakes are this high, we can’t go it alone. BIO unites a global network of business leaders, policymakers, investors and scientists for a common purpose: curing patients, protecting the planet, and nourishing humanity.
| Friday June 7 7 | Saturday June 8 8 | Sunday June 9 9 |